TY - JOUR
T1 - Fabrication, Characterization and Biological Evaluation of PRGD/PDLLA/β-TCP Scaffold for Nerve Regeneration
JO - Journal of Fiber Bioengineering and Informatics
VL - 1
SP - 133
EP - 142
PY - 2015
DA - 2015/08
SN - 8
DO - http://doi.org/10.3993/jfbi03201513
UR - https://global-sci.org/intro/article_detail/jfbi/4693.html
KW - Schwann Cells
KW - PRGD ⁄ PDLLA ⁄ β-TCP Composite
KW - Implantation
KW - Inflammatory Factors
KW - Biocompatibility
AB - A novel nerve repairing material PRGD/PDLLA/β-TCP was synthesized and characterized with
Scanning Electron Microscope (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and mass loss
ratio. The effects of PDLLA or PRGD/PDLLA/β-TCP on viability and growth of Schwann Cells
(SCs) were investigated by MTT assay and SEM. After implantation of different materials, histological
assessment was performed. The results showed that, compared with PDLLA, PRGD/PDLLA/β-TCP
materials displayed better biocompatibility, degradation property and less inflammatory reaction.
Moreover, PRGD/PDLLA/β-TCP materials promoted the adhesion and proliferation of Schwann cells
and exhibited better degradation performance than pure PDLLA. These results indicated that PRGD/
PDLLA/β-TCP has a potential application in the fields of nerve regeneration.