@Article{IJNAM-13-2,
author = {},
title = {Transient Feedback and Robust Signaling Gradients},
journal = {International Journal of Numerical Analysis and Modeling},
year = {2016},
volume = {13},
number = {2},
pages = {179--204},
abstract = {<p style="text-align: justify;">Robust development of biological organisms in the presence of genetic and epi-genetic
perturbations is important for time spans short relative to evolutionary time. Gradients of receptor
bound signaling morphogens are responsible for patterning formation and development. A
variety of inhibitors for reducing ectopic signaling activities are known to exist and their specific
role in down-regulating the undesirable ectopic activities reasonably well understood. However,
how a developing organism manages to adjust inhibition/stimulation in response to genetic and/or
environmental changes remains to be uncovered. The need to adjust for ectopic signaling activities
requires the presence of one or more feedback mechanisms to stimulate the needed adjustment.
As the ultimate effect of many inhibitors (including those of the nonreceptor type) is to reduce the
availability of signaling morphogens for binding with signaling receptors, a negative feedback on
signaling morphogen synthesis rate based on a root-mean-square measure of the spatial distribution
of signaling concentration offers a simple approach to robusness and has been demonstrated
to be effective in a proof-of-concept implementation. In this paper, we complement the previous
investigation of feedback in steady state by examining the effect of one or more feedback
adjustments during the transient phase of the biological development.</p>},
issn = {2617-8710},
doi = {https://doi.org/2016-IJNAM-433},
url = {https://global-sci.com/article/83229/transient-feedback-and-robust-signaling-gradients}
}