@Article{JNMA-2-3,
author = {Li, Jiemei and Xiaofei, Wei and Zhang, Jianmei},
title = {Modeling Influence of Raltegravir Intensification on Viral Dynamics: Stability and Hopf Bifurcation},
journal = {Journal of Nonlinear Modeling and Analysis},
year = {2020},
volume = {2},
number = {3},
pages = {467--483},
abstract = {<p style="text-align: justify;">In this paper, we propose an ordinary differential equation model with logistic target cell growth to describe influence of raltegravir intensification on viral dynamics. The basic reproduction number $R_0$ is established. The infection-free equilibrium $E_0$ is globally attractive if $R_0 &lt; 1$, while virus is uniformly persistent if $R_0 &gt; 1$. In addition, we find that Hopf bifurcation can occur at around the positive equilibrium within certain parameter ranges. Numerical simulations are performed to illustrate theoretical results.</p>},
issn = {2562-2862},
doi = {https://doi.org/10.12150/jnma.2020.467},
url = {https://global-sci.com/article/88024/modeling-influence-of-raltegravir-intensification-on-viral-dynamics-stability-and-hopf-bifurcation}
}