A Mechano-Electrochemical Model of Brain Neuro-Mechanics: Application to Normal Pressure Hydrocephal
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@Article{IJNAMB-3-82,
author = {CORINA S. DRAPACA AND JASON S. FRITZ},
title = {A Mechano-Electrochemical Model of Brain Neuro-Mechanics: Application to Normal Pressure Hydrocephal},
journal = {International Journal of Numerical Analysis Modeling Series B},
year = {2012},
volume = {3},
number = {1},
pages = {82--93},
abstract = {Normal pressure hydrocephalus (NPH) is a neurological condition that occurs in adults usually older than sixty years, characterized by an excessive accumulation of celebrospinal
fluid in the brain ventricles in the absence of an elevated intracranial pressure. Although the first
description of this disease has been given in 1965 by Hakim and Adams, the progress in improving
the diagnosis and treatment outcome of NPH has been slow due mainly to the fact that the causes
of NPH continue to remain unknown in most of the cases. The few existing biomechanical models
of NPH existing in the literature are based on the bulk flow theory which requires an increased
intracranial pressure and thus fail to properly explain the onset of NPH. The aim of the present
paper is to formulate the first neuro-mechanical model that will couple the electro-chemical and
mechanical properties of the brain. We assume that the brain tissue is a charged hydrated soft
tissue made of a solid phase, an interstitial fluid phase and an ion phase with (for now) two
monovalent ion species. Using our model, we will show that NPH could be caused by a change
in the concentrations of Na^+ and Cl^- in the ventricular cerebrospinal fluid in the absence of an
elevated intracranial pressure.},
issn = {},
doi = {https://doi.org/},
url = {http://global-sci.org/intro/article_detail/ijnamb/272.html}
}
TY - JOUR
T1 - A Mechano-Electrochemical Model of Brain Neuro-Mechanics: Application to Normal Pressure Hydrocephal
AU - CORINA S. DRAPACA AND JASON S. FRITZ
JO - International Journal of Numerical Analysis Modeling Series B
VL - 1
SP - 82
EP - 93
PY - 2012
DA - 2012/03
SN - 3
DO - http://doi.org/
UR - https://global-sci.org/intro/article_detail/ijnamb/272.html
KW - brain neuro-mechanics
KW - triphasic model
KW - normal pressure hydrocephalus
KW - brain swelling
AB - Normal pressure hydrocephalus (NPH) is a neurological condition that occurs in adults usually older than sixty years, characterized by an excessive accumulation of celebrospinal
fluid in the brain ventricles in the absence of an elevated intracranial pressure. Although the first
description of this disease has been given in 1965 by Hakim and Adams, the progress in improving
the diagnosis and treatment outcome of NPH has been slow due mainly to the fact that the causes
of NPH continue to remain unknown in most of the cases. The few existing biomechanical models
of NPH existing in the literature are based on the bulk flow theory which requires an increased
intracranial pressure and thus fail to properly explain the onset of NPH. The aim of the present
paper is to formulate the first neuro-mechanical model that will couple the electro-chemical and
mechanical properties of the brain. We assume that the brain tissue is a charged hydrated soft
tissue made of a solid phase, an interstitial fluid phase and an ion phase with (for now) two
monovalent ion species. Using our model, we will show that NPH could be caused by a change
in the concentrations of Na^+ and Cl^- in the ventricular cerebrospinal fluid in the absence of an
elevated intracranial pressure.
CORINA S. DRAPACA AND JASON S. FRITZ. (1970). A Mechano-Electrochemical Model of Brain Neuro-Mechanics: Application to Normal Pressure Hydrocephal.
International Journal of Numerical Analysis Modeling Series B. 3 (1).
82-93.
doi:
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