Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network
Year: 2022
Author: T. Lin, Z. Wang, R. X. Lu, W. Wang, Y. Sui
Advances in Applied Mathematics and Mechanics, Vol. 14 (2022), Iss. 1 : pp. 79–100
Abstract
Deformable microcapsules are widely used in industries and also serve as a mechanical model of living biological cells. In this study, we develop a novel method, by integrating a deep convolutional neural network (DCNN) with high-fidelity mechanistic capsule modelling, to identify the membrane constitutive law and estimate associated parameters of a microcapsule from its steady deformed profile in a capillary tube. Compared with conventional inverse methods, the present approach is more accurate and can increase the prediction throughput rate by a few orders of magnitude. It can process capsules with large deformation in inertial flows. Furthermore, the method can predict the capsule membrane shear elasticity, area dilatation modulus and initial inflation from a single steady capsule profile. We explore the mechanism that the DCNN makes decisions by considering its feature maps, and discuss their potential implication on the development of inverse methods. The present method provides a promising tool which may enable high-throughput mechanical characterisation of microcapsules and biological cells in microfluidic flows.
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Journal Article Details
Publisher Name: Global Science Press
Language: English
DOI: https://doi.org/10.4208/aamm.OA-2020-0357
Advances in Applied Mathematics and Mechanics, Vol. 14 (2022), Iss. 1 : pp. 79–100
Published online: 2022-01
AMS Subject Headings: Global Science Press
Copyright: COPYRIGHT: © Global Science Press
Pages: 22
Keywords: Microcapsules flow cytometry deep convolutional neural network high throughput mechanical characterisation.
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