Year: 2011
Author: Huaxiong Huang, Robert M. Miura, Wei Yao
Advances in Applied Mathematics and Mechanics, Vol. 3 (2011), Iss. 6 : pp. 759–773
Abstract
In this paper, we construct a simplified neuronal model that is capable of simulating the instigation of cortical spreading depression (CSD) and propagation of a CSD wave. Our model is a simplification and extension of a single neuron model proposed in the literature for studying the instigation of CSD. Using the simplified neuronal model, we construct a network of these simplified neurons. This network model shows that the propagation of a CSD wave occurs naturally after it is instigated electrically or chemically. Although the model is simple, the speed of the CSD wave predicted by our model is consistent with experimentally observed values. Finally, our model allows us to investigate the effects of specific ion channels on the spread of a CSD wave.
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Journal Article Details
Publisher Name: Global Science Press
Language: English
DOI: https://doi.org/10.4208/aamm.10-m1052
Advances in Applied Mathematics and Mechanics, Vol. 3 (2011), Iss. 6 : pp. 759–773
Published online: 2011-01
AMS Subject Headings: Global Science Press
Copyright: COPYRIGHT: © Global Science Press
Pages: 15
Keywords: Cortical spreading depression neuronal model network numerical simulation.
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