The Properties of Glycophorin a Transmembrane Helices in Erythrocyte Asymmetric Membrane: A Molecular Dynamics Study

The Properties of Glycophorin a Transmembrane Helices in Erythrocyte Asymmetric Membrane: A Molecular Dynamics Study

Year:    2011

Author:    Paruyr K. Hakobyan, Armen H. Poghosyan, Aram A. Shahinyan

Journal of Atomic and Molecular Sciences, Vol. 2 (2011), Iss. 4 : pp. 281–288

Abstract

We have performed an 80ns molecular dynamics (MD) simulation of human red blood erythrocyte asymmetric membrane model. The NAMD code and CHARMM27 force field were used. We have estimated some features of embedded Glycophorin A (GpA) protein and have discussed some important problems concerning the interaction between the protein and surrounding media. It is stated that the lipid environment and protein immediate neighboring lead to the changes in helix-helix association, as well as to the protein orientation. The interaction nature between protein and neighboring phospholipid chains are dominant forces governing to helix-helix association.

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Journal Article Details

Publisher Name:    Global Science Press

Language:    English

DOI:    https://doi.org/10.4208/jams.012711.021511a

Journal of Atomic and Molecular Sciences, Vol. 2 (2011), Iss. 4 : pp. 281–288

Published online:    2011-01

AMS Subject Headings:    Global Science Press

Copyright:    COPYRIGHT: © Global Science Press

Pages:    8

Keywords:    Glycophorin A (GpA) protein erythrocyte membrane molecular dynamics simulation helix-helix association.

Author Details

Paruyr K. Hakobyan

Armen H. Poghosyan

Aram A. Shahinyan