Year: 2009
Communications in Computational Physics, Vol. 5 (2009), Iss. 5 : pp. 871–896
Abstract
Stochastic well-stirred chemically reacting systems can be accurately modeled by a continuous-time Markov-chain. The corresponding master equation evolves the system's probability density function in time but can only rarely be explicitly solved. We investigate a numerical solution strategy in the form of a spectral method with an inherent natural adaptivity and a very favorable choice of basis functions. Theoretical results related to convergence have been developed previously and are briefly summarized while implementation issues, including how to adapt the basis functions to follow the solution they represent, are covered in more detail here. The method is first applied to a model problem where the convergence can easily be studied. Then we take on two more realistic systems from molecular biology where stochastic descriptions are often necessary to explain experimental data. The conclusion is that, for sufficient accuracy demands and not too high dimensionality, the method indeed provides an alternative to other methods.
You do not have full access to this article.
Already a Subscriber? Sign in as an individual or via your institution
Journal Article Details
Publisher Name: Global Science Press
Language: English
DOI: https://doi.org/2009-CiCP-7768
Communications in Computational Physics, Vol. 5 (2009), Iss. 5 : pp. 871–896
Published online: 2009-01
AMS Subject Headings: Global Science Press
Copyright: COPYRIGHT: © Global Science Press
Pages: 26