Fabrication, Characterization and Biological Evaluation of PRGD/PDLLA/β-TCP Scaffold for Nerve Regeneration
Year: 2015
Journal of Fiber Bioengineering and Informatics, Vol. 8 (2015), Iss. 1 : pp. 133–142
Abstract
A novel nerve repairing material PRGD/PDLLA/β-TCP was synthesized and characterized with Scanning Electron Microscope (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and mass loss ratio. The effects of PDLLA or PRGD/PDLLA/β-TCP on viability and growth of Schwann Cells (SCs) were investigated by MTT assay and SEM. After implantation of different materials, histological assessment was performed. The results showed that, compared with PDLLA, PRGD/PDLLA/β-TCP materials displayed better biocompatibility, degradation property and less inflammatory reaction. Moreover, PRGD/PDLLA/β-TCP materials promoted the adhesion and proliferation of Schwann cells and exhibited better degradation performance than pure PDLLA. These results indicated that PRGD/ PDLLA/β-TCP has a potential application in the fields of nerve regeneration.
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Journal Article Details
Publisher Name: Global Science Press
Language: English
DOI: https://doi.org/10.3993/jfbi03201513
Journal of Fiber Bioengineering and Informatics, Vol. 8 (2015), Iss. 1 : pp. 133–142
Published online: 2015-01
AMS Subject Headings:
Copyright: COPYRIGHT: © Global Science Press
Pages: 10
Keywords: Schwann Cells
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Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/ -TCP conduit: report of two cases
Yin, Y.
Li, B.
Yan, Q.
Dai, H.
Wang, X.
Huang, J.
Li, S.
Regenerative Biomaterials, Vol. 2 (2015), Iss. 2 P.119
https://doi.org/10.1093/rb/rbv006 [Citations: 9]