Effect of Operating Parameters on Yield and Anti-Oxidative Activity of Puerarin in Supercritical Process
Year: 2009
Journal of Fiber Bioengineering and Informatics, Vol. 2 (2009), Iss. 3 : pp. 189–196
Abstract
Puerarin particles were prepared in the process of solution-enhanced dispersion by supercritical CO_2 (SEDS), where the dichloromethane was employed as an organic non-solvent to increase the saturation ratio of the initial puerarin solution in ethanol. A 2^3 factorial experiment was designed to investigate and identify the relative significance of the processing parameters on the yield of puerarin. In the range of the parameters studied, the yield increased with an increasing non-solvent/solvent ratio, and decreasing puerarin concentration or flow rate. The anti-oxidative activities of puerarin prepared under different parameters were also investigated, and the results show that there is no significant difference. The results indicate that the SEDS process combined with non-solvent could produce puerarin nanoparticles with a higher yield.
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Journal Article Details
Publisher Name: Global Science Press
Language: English
DOI: https://doi.org/10.3993/jfbi12200909
Journal of Fiber Bioengineering and Informatics, Vol. 2 (2009), Iss. 3 : pp. 189–196
Published online: 2009-01
AMS Subject Headings:
Copyright: COPYRIGHT: © Global Science Press
Pages: 8
Keywords: Puerarin